PELCO® easiSlicer™ Tissue Adhesive: A Versatile Solution for Tissue Preparation and Slide Applications

The PELCO® easiSlicer™ Tissue Adhesive is a fast-acting, cyanoacrylate-based adhesive specially formulated for vibratory tissue slicing applications. With its quick-set properties, it ensures the secure and efficient mounting of tissue specimens onto specimen holders, making it an indispensable tool for researchers and lab professionals working with vibrating microtomes like the PELCO easiSlicer™, Microslicer™, Vibratome®, and other similar devices.

Key Features and Benefits

Quick-Setting Formula: Designed for rapid adhesion, enabling smooth workflows and reducing waiting times during tissue preparation.
Precise Application: The adhesive comes in a convenient 10ml (0.33 oz./9.3g) bottle with a dispenser tip for precise control, minimizing waste and ensuring accurate placement.
Optimal Sealing: A PTFE-coated steel pin closure maintains the adhesive's integrity, preventing drying or clogging and ensuring reliable performance over time.
Biocompatibility: Formulated specifically for sensitive tissue applications, ensuring compatibility with biological specimens.

Applications

Vibratory Tissue Slicing:
Ideal for securely mounting delicate tissue samples onto specimen holders for use with vibrating microtomes.
Ensures the stability of samples during sectioning, resulting in clean and precise slices for histology, electrophysiology, and imaging studies.
Tissue-Slide Mounting:
Suitable for quick-set mounting of tissue samples onto microscope slides for histopathology, immunohistochemistry, or staining procedures.
Provides a reliable bond that maintains tissue integrity throughout processing and analysis.
Neuroscience and Brain Tissue Studies:
Widely used in neuroanatomy and brain tissue slicing applications, where precision and sample stability are critical for studying neural structures and pathways.
Biological and Biomedical Research:
Applicable for various tissue preparation techniques in cell biology, developmental biology, and pharmacological studies.
Facilitates the preparation of tissue sections for fluorescence and confocal microscopy.
Versatile Adhesion Needs:
Beyond vibratory slicing, the adhesive can be employed for any laboratory application requiring quick-setting adhesion, such as temporarily bonding small components or samples during experimental setups.

Storage and Handling Tips

Extended Shelf Life: Store the adhesive at -20°C to significantly extend its usability. When ready to use, allow it to thaw at room temperature with the container sealed to avoid condensation affecting the product.
Cleanup: Use the PELCO® Pro Cyanoacrylate Debonder (#19920) to clean or remove cured adhesive effectively from surfaces or equipment.
Caution: The adhesive is unstable in boiling water, so avoid exposing bonded specimens to high-temperature processes.

The PELCO® easiSlicer™ Tissue Adhesive is a reliable and versatile solution for labs requiring precision, speed, and dependability in tissue preparation. Whether you’re working with vibrating microtomes, slide mounting, or other biological applications, this adhesive ensures excellent results every time.

More details from Manufacturer:-

LOCTITE® 404: Low-Viscosity Instant Adhesive for Plastics and Elastomers

LOCTITE® 404 is a transparent, colorless to straw-colored, industrial-grade, low-viscosity adhesive designed specifically for rapid bonding of plastics and elastomeric materials. Known for its fast fixturing capability, it simplifies assembly processes and is ideal for quick repairs. This adhesive has been qualified to Commercial Item Description A-A-3097 (a regional approval).

Key Features and Applications

O-Ring Assembly: Ideal for assembling or repairing O-rings quickly and effectively.
Rubber and Plastics Bonding: Designed for optimal adhesion to rubber (elastomeric materials) and plastic surfaces.
Fast Repairs: Perfect for situations requiring rapid fixes.
Commercial Approval: Qualified to meet the standards of A-A-3097 (regional certification).

How to Use LOCTITE® 404

Surface Preparation – Cleaning
Clean and degrease surfaces with an appropriate LOCTITE® cleaner (e.g., LOCTITE® SF 7070) before applying the adhesive.
Surface Preparation – Priming
For challenging plastic surfaces, improve adhesion by applying LOCTITE® SF 770 primer using a brush or dip method. Avoid excessive primer application and allow it to dry completely.
Preparation – Activation
If the curing speed is insufficient, use LOCTITE® SF 7452 activator. Apply the activator to one bonding surface via spray, brush, or dipping (do not apply on primed surfaces). Allow the activator to dry before proceeding.
Adhesive Application
Apply a small amount of adhesive to one of the parts to be bonded.
Assembly
Immediately assemble the parts, ensuring they are accurately aligned since the quick fixture time leaves little room for adjustment. Hold or clamp the parts until the adhesive is securely fixtured.
To cure any excess adhesive, apply LOCTITE® SF 7452 activator by spray or drop method.
Pro Tip: Use dispensing needles for precise application of small adhesive amounts.

Frequently Asked Questions

1. Are there solutions for quickly creating replacement O-rings?

Yes, LOCTITE® 404, also available in the LOCTITE® O-ring Splicing Kit (IDH 228171), allows you to create high-performance O-rings in under a minute. It’s an excellent backup solution to avoid stock shortages and ideal for field repairs.

2. Why do plastics sometimes crack when using instant adhesives?

This is due to stress cracking caused by uncured liquid adhesive left on stressed plastic substrates (e.g., polycarbonate, acrylic, or polysulfone). To minimize this issue:
Close the bond joint quickly.
Use reinforced grades of plastic.
Anneal parts before bonding.
Speed up adhesive curing using an accelerator or light (for light-curable adhesives).

3. What causes a white haze around the bonded area?

This phenomenon, known as blooming, results from excessive product application. To reduce blooming:
Use proper ventilation.
Apply less product.
Work in lower humidity conditions.
Use a primer/accelerator or low-bloom adhesive.

4. Should instant adhesives be refrigerated?

Yes, unopened instant adhesives should be stored in a refrigerator to extend shelf life. Once opened, DO NOT refrigerate them; instead, use the product within 30 days for optimal performance.

5. What health and safety precautions are necessary for this product?

Refer to the product's Material Safety Data Sheet (MSDS) for complete H&S guidelines and PPE requirements.

LOCTITE® 404 provides a reliable, efficient solution for bonding plastics and elastomers, ensuring quick fixes and strong, durable bonds. For more details or purchasing information, visit your authorized LOCTITE® distributor or contact their technical support team.

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Loctite® 404 Quick-Set

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