*This document is like a lab demo—an example Certificate of Analysis (COA) that showcases what a COA looks like but may not match the latest batch in all its glory. Think of it as a chemistry experiment: close, but not quite the final reaction!
Propionic acid is a colorless liquid with a sharp rancid odor. Produces irritating vapor.
Propionic acid, [solution] appears as a clear oily aqueous liquid with a pungent rancid odor. Burns skin and the vapors irritate mucous membranes. Corrosive to most metals and tissue.
Propionic acid is a short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group. It has a role as an antifungal drug. It is a short-chain fatty acid and a saturated fatty acid. It is a conjugate acid of a propionate.
Sodium propionate is the sodium salt of propionic acid that exists as colorless, transparent crystals or a granular crystalline powder. It is considered generally recognized as safe food ingredient by FDA, where it acts as an antimicrobial agent for food preservation and flavoring agent. Its use as a food additive is also approved in Europe. Sodium propionate is is prepared by neutralizing propionic acid with sodium hydroxide. Sodium propionate was previously approved in Canada as an active ingredient in Amino-Cerv .
Propionic acid is a metabolite found in or produced by Escherichia coli .
Propionic Acid has been reported in Ipomoea leptophylla, Angelica gigas, and other organisms with data available.
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PROPIONIC ACID is a small molecule drug with a maximum clinical trial phase of II.
Zinc proprionate is a chemical compound of zinc. Zinc is a metallic element with the atomic number 30. It is found in nature most often as the mineral sphalerite. Though excess zinc in harmful, in smaller amounts it is an essential element for life, as it is a cofactor for over 300 enzymes and is found in just as many transcription factors.
Propionic acid is widely used as an antifungal agent in food. It is present naturally at low levels in dairy products and occurs ubiquitously, together with other short-chain fatty acids , in the gastro-intestinal tract of humans and other mammals as an end-product of the microbial digestion of carbohydrates. It has significant physiological activity in animals. PA is irritant but produces no acute systemic effects and has no demonstrable genotoxic potential. Propionic aciduria is one of the most frequent organic acidurias, a disease that comprise many various disorders. The outcome of patients born with Propionic aciduria is poor intellectual development patterns, with 60% having an IQ less than 75 and requiring special education. Successful liver and/or renal transplantations, in a few patients, have resulted in better quality of life but have not necessarily prevented neurological and various visceral complications. These results emphasize the need for permanent metabolic follow-up whatever the therapeutic strategy. Decreased early mortality, less severe symptoms at diagnosis, and more favorable short-term neurodevelopmental outcome were recorded in patients identified through expanded newborn screening. .
propionic acid is a metabolite found in or produced by Saccharomyces cerevisiae.
Computed Properties
Molecular Weight:
74.08 g/mol
XLogP3:
0.3
Hydrogen Bond Donor Count:
1
Hydrogen Bond Acceptor Count:
2
Rotatable Bond Count:
1
Exact Mass:
74.036779430 Da
Monoisotopic Mass:
74.036779430 Da
Topological Polar Surface Area:
37.3 Ų
Heavy Atom Count:
5
Formal Charge:
0
Complexity:
40.2
Isotope Atom Count:
0
Defined Atom Stereocenter Count:
0
Undefined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Covalently-Bonded Unit Count:
1
Compound Is Canonicalized:
Yes
hazard signal
Danger
hazard classes and categories
Flam. Liq. 3 (20.3%)
Skin Corr. 1B (100%)
Eye Dam. 1 (18.3%)
STOT SE 3 (16.9%)
Not Classified
Acute toxicity - category 3
Acute toxicity - category 4
Skin corrosion - category 1B
Specific target organ toxicity (single exposure) - category 3
Flammable liquids - Category 3
Acute toxicity (Dermal) - Category 3
Skin corrosion/irritation - Category 1
Serious eye damage/eye irritation - Category 1
Specific target organ toxicity - Single exposure - Category 3 (Respiratory tract irritation)
Hazardous to the aquatic environment (Acute) - Category 3
Acute toxicity (Oral) - Category 5
Skin corrosion/irritation - Category 1A-1C
Hazardous to the aquatic environment (Long-term) - Category 3
H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
hazards summary
Liquid causes second degree burns after contact for a few minutes. Corrosive to skin. A skin, eye, and respiratory tract irritant.
toxicity summary
Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis . Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. In healthy individuals, the enzyme propionyl CoA carboxylase converts propionyl CoA to methylmalonyl CoA. This is one step in the process of converting certain amino acids and fats into sugar for energy. Individuals with propionic acidemia cannot perform this conversion because the enzyme propionyl CoA carboxylase is nonfunctional. The essential amino acids; isoleucine, valine, threonine, and methionine and odd-chain fatty acids are simply converted to propionyl CoA, before the process stops, leading to a buildup of propionyl CoA. Instead of being converted to methylmalonyl CoA, propionyl CoA is then converted into propionic acid, which builds up in the bloodstream. Propionyl-CoA, propionic acid, ketones, ammonia, and other toxic compounds accumulate in the blood, causing the signs and symptoms of propionic acidemia. Propionate acts as a metabolic toxin in liver cells by accumulating in mitochondria. Propanoate is metabolized oxidatively by glia, which suggests astrocytic vulnerability in propanoic acidemia when intramitochondrial propionyl-CoA may accumulate. Propanoic acidemia may alter both neuronal and glial gene expression by affecting histone acetylation .
symptoms
health effects
Chronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage.
carcinogen classification
default_key:
No indication of carcinogenicity to humans .
carcinogen classification
default_key:
No indication of carcinogenicity to humans .
PROPIONIC ACID 99% For Synthesis 79-09-4 | Chempure
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