| hazard signal | Warning |
| hazard classes and categories | Acute Tox. 4 (99.96%)STOT RE 2 (26.95%)Not ClassifiedAcute toxicity - category 4Specific target organ toxicity (single exposure) - category 3Acute toxicity (Inhalation: Dusts and mists) - Category 4Skin corrosion/irritation - Category 2Serious eye damage/eye irritation - Category 2BSpecific target organ toxicity - Single exposure - Category 1 (central nervous system, blood system, kidney), Category 3 (respiratory tract irritation, narcotic effects)Acute toxicity (Oral) - Category 5Skin corrosion/irritation - Category 3Reproductive toxicity - Category 1BSpecific target organ toxicity - Single exposure - Category 1 (central nervous system, kidney, heart, respiratory system)Specific target organ toxicity - Repeated exposure - Category 1 (central nervous system, respiratory system, heart)Acute Tox. 4 * |
| precautionary statement codes | P260, P264, P270, P301+P317, P319, P330, and P501 |
| hazard statements | H302 (99.96%): Harmful if swallowed [Warning Acute toxicity, oral]H373 (26.95%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] |
| hazards summary | Ethylene glycol is a synthetic liquid substance that absorbs water. It is odorless, but has a sweet taste. Ethylene glycol is used to make antifreeze and de-icing solutions for cars, airplanes, and boats. It is also used in hydraulic brake fluids and inks used in stamp pads, ballpoint pens, and print shops.Ethylene glycol has many uses, including as antifreeze in cooling and heating systems, in hydraulic brake fluids, and as a solvent. Acute (short-term) exposure of humans to ethylene glycol by ingesting large quantities causes three stages of health effects: central nervous system (CNS) depression, followed by cardiopulmonary effects, and later renal damage. The only effects noted in one study of individuals exposed to low levels of ethylene glycol by inhalation for about a month were throat and upper respiratory tract irritation. Rats and mice chronically (long-term) exposed to ethylene glycol in their diet exhibited signs of kidney toxicity and liver effects. Several studies of rodents exposed orally or by inhalation showed ethylene glycol to be fetotoxic. An epidemiologic study on renal cancer mortality did not find an increased risk for workers exposed to ethylene glycol. EPA has not classified ethylene glycol for carcinogenicity.TLV Basis is upper respiratory tract irritation. The oral lethal dose in adult humans is about 1.4 ml/kg or about 100 ml. No adverse effects to human eyes after 4 weeks of exposure to 6.6 ppm. Ethylene glycol is a skin irritant and a poison by ingestion. No health effects have been reported in persons chronically exposed to levels of ethylene glycol found in the environment. Toxic inhalation of ethylene glycol is unlikely at room temperature because of the chemical's low volatility, but can occur when the liquid is heated, agitated, or sprayed. Toxicity after ingestion includes inebriation, metabolic acidosis, and renal failure. Ethylene glycol is not significantly absorbed through the skin. Poisoning after inhalation exposure is unlikely. Combined osmolar and anion gaps suggest poisoning by methanol or ethylene glycol, but also may occur in severe alcoholic ketoacidosis or diabetic ketoacidosis. A skin, eye, and respiratory tract irritant. May cause effects on the kidneys and CNS. Causes acute tubular necrosis after ingestion but not after occupational exposures because of low vapor pressure. |