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Product No: EE1068

CURCUMIN CRYSTALLINE 95% Extra Pure

Name: CURCUMIN CRYSTALLINE 95% Extra Pure
Brand: Chempure
Rating: 4 (1 reviews)

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CAS Number

458-37-7

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IUPAC name	(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
canonical smiles	COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
inchi	InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
inchi key	VFLDPWHFBUODDF-FCXRPNKRSA-N
molecular formula	C21H20O6
synonyms	curcumin 458-37-7 Diferuloylmethane Natural yellow 3 Kacha haldi
Compound Description	Curcumin appears as orange-yellow needles. Curcumin is a beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa. It has a role as a metabolite, an anti-inflammatory agent, an antineoplastic agent, a hepatoprotective agent, a flavouring agent, a biological pigment, a nutraceutical, an antifungal agent, a dye, a lipoxygenase inhibitor, a ligand, a radical scavenger, a contraceptive drug, an EC 3.5.1.98 inhibitor, an immunomodulator, an iron chelator, a neuroprotective agent, a food colouring, an EC 1.1.1.21 inhibitor, an EC 1.1.1.25 inhibitor, an EC 1.1.1.205 inhibitor, an EC 1.6.5.2 [NADH dehydrogenase ] inhibitor, an EC 1.8.1.9 inhibitor, an EC 2.7.10.2 inhibitor and a geroprotector. It is a polyphenol, a beta-diketone, an enone, a diarylheptanoid and an aromatic ether. It is functionally related to a ferulic acid. Curcumin, also known as diferuloylmethane, is an active component in the golden spice turmeric and in [Curcuma xanthorrhiza oil]. It is a highly pleiotropic molecule that exhibits antibacterial, anti-inflammatory, hypoglycemic, antioxidant, wound-healing, and antimicrobial activities. Due to these properties, curcumin has been investigated for the treatment and supportive care of clinical conditions including proteinuria, breast cancer, multiple myeloma, depression, and Non Small Cell Lung Cancer . Despite proven efficacy against numerous experimental models, poor bioavailability due to poor absorption, rapid metabolism, and rapid systemic elimination have been shown to limit the therapeutic efficacy of curcumin. Curcumin is under investigation for the treatment and supportive care of various clinical conditions including mucositis, rectal cancer, prostate cancer, chronic schizophrenia, and Mild Cognitive Impairment . curcumin is a metabolite found in or produced by Escherichia coli . Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin blocks the formation of reactive-oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agent's observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer. A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes. See also: ... View More ...

Computed Properties

Molecular Weight:	368.4 g/mol
XLogP3:	3.2
Hydrogen Bond Donor Count:	2
Hydrogen Bond Acceptor Count:	6
Rotatable Bond Count:	8
Exact Mass:	368.12598835 g/mol
Monoisotopic Mass:	368.12598835 g/mol
Topological Polar Surface Area:	93.1 Å²
Heavy Atom Count:	27
Formal Charge:	0
Complexity:	507
Isotope Atom Count:	0
Defined Atom Stereocenter Count:	0
Undefined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	2
Undefined Bond Stereocenter Count:	0
Covalently-Bonded Unit Count:	1
Compound Is Canonicalized:	Yes

Related Compounds

Curcumin

Tetrahydrocurcumin

Bisdemethoxycurcumin

Shogaol

Demethoxycurcumin

Dehydrozingerone

Gingerenone A

(1E,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one

p-Hydroxyphenethyl trans-ferulate

1-(4-Hydroxy-3-methoxyphenyl)-4-decen-3-one

p-Hydroxy-curucumin

(8)-Shogaol

(10)-Shogaol

Dimethoxycurcumin

(E)-1-(4-Hydroxy-3-methoxyphenyl)hexadec-4-en-3-one

hazard signal	Warning
hazard classes and categories	Skin Irrit. 2 (99.33%) Eye Irrit. 2 (100%) STOT SE 3 (100%) Skin Irrit. 2 (100%)
precautionary statement codes	P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
hazard statements	H315 (99.33%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
hazards summary	This compound is an allergen and local irritant. Curcumin is not a reproductive toxin in mice. Allowable daily intake = 0-3 mg/kg bw. An irritant. May be harmful if swallowed.

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Documentation

Certificate of Analysis

Lot Number

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CAS #

*This document is like a lab demo—an example Certificate of Analysis (COA) that showcases what a COA looks like but may not match the latest batch in all its glory. Think of it as a chemistry experiment: close, but not quite the final reaction!

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About this item

IUPAC name	(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
canonical smiles	COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
inchi	InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
inchi key	VFLDPWHFBUODDF-FCXRPNKRSA-N
molecular formula	C21H20O6
synonyms	curcumin 458-37-7 Diferuloylmethane Natural yellow 3 Kacha haldi
Compound Description	Curcumin appears as orange-yellow needles. Curcumin is a beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa. It has a role as a metabolite, an anti-inflammatory agent, an antineoplastic agent, a hepatoprotective agent, a flavouring agent, a biological pigment, a nutraceutical, an antifungal agent, a dye, a lipoxygenase inhibitor, a ligand, a radical scavenger, a contraceptive drug, an EC 3.5.1.98 inhibitor, an immunomodulator, an iron chelator, a neuroprotective agent, a food colouring, an EC 1.1.1.21 inhibitor, an EC 1.1.1.25 inhibitor, an EC 1.1.1.205 inhibitor, an EC 1.6.5.2 [NADH dehydrogenase ] inhibitor, an EC 1.8.1.9 inhibitor, an EC 2.7.10.2 inhibitor and a geroprotector. It is a polyphenol, a beta-diketone, an enone, a diarylheptanoid and an aromatic ether. It is functionally related to a ferulic acid. Curcumin, also known as diferuloylmethane, is an active component in the golden spice turmeric and in [Curcuma xanthorrhiza oil]. It is a highly pleiotropic molecule that exhibits antibacterial, anti-inflammatory, hypoglycemic, antioxidant, wound-healing, and antimicrobial activities. Due to these properties, curcumin has been investigated for the treatment and supportive care of clinical conditions including proteinuria, breast cancer, multiple myeloma, depression, and Non Small Cell Lung Cancer . Despite proven efficacy against numerous experimental models, poor bioavailability due to poor absorption, rapid metabolism, and rapid systemic elimination have been shown to limit the therapeutic efficacy of curcumin. Curcumin is under investigation for the treatment and supportive care of various clinical conditions including mucositis, rectal cancer, prostate cancer, chronic schizophrenia, and Mild Cognitive Impairment . curcumin is a metabolite found in or produced by Escherichia coli . Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin blocks the formation of reactive-oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agent's observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer. A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes. See also: ... View More ...

Computed Properties

Molecular Weight:	368.4 g/mol
XLogP3:	3.2
Hydrogen Bond Donor Count:	2
Hydrogen Bond Acceptor Count:	6
Rotatable Bond Count:	8
Exact Mass:	368.12598835 g/mol
Monoisotopic Mass:	368.12598835 g/mol
Topological Polar Surface Area:	93.1 Å²
Heavy Atom Count:	27
Formal Charge:	0
Complexity:	507
Isotope Atom Count:	0
Defined Atom Stereocenter Count:	0
Undefined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	2
Undefined Bond Stereocenter Count:	0
Covalently-Bonded Unit Count:	1
Compound Is Canonicalized:	Yes

Related Compounds

Curcumin

Tetrahydrocurcumin

Bisdemethoxycurcumin

Shogaol

Demethoxycurcumin

Dehydrozingerone

Gingerenone A

(1E,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one

p-Hydroxyphenethyl trans-ferulate

1-(4-Hydroxy-3-methoxyphenyl)-4-decen-3-one

p-Hydroxy-curucumin

(8)-Shogaol

(10)-Shogaol

Dimethoxycurcumin

(E)-1-(4-Hydroxy-3-methoxyphenyl)hexadec-4-en-3-one

hazard signal	Warning
hazard classes and categories	Skin Irrit. 2 (99.33%) Eye Irrit. 2 (100%) STOT SE 3 (100%) Skin Irrit. 2 (100%)
precautionary statement codes	P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
hazard statements	H315 (99.33%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
hazards summary	This compound is an allergen and local irritant. Curcumin is not a reproductive toxin in mice. Allowable daily intake = 0-3 mg/kg bw. An irritant. May be harmful if swallowed.

Product No: EE1068

CURCUMIN CRYSTALLINE 95% Extra Pure

Product No: EE1068

About this item

NAME AND IDENTIFIERS

CHEMICAL AND PHYSICAL PROPERTIES

Related Compounds

SAFETY AND HAZARDS

About this item

Documentation

Certificate of Analysis

Require a Sample Certificate of Analysis (COA) ?

Reviews

Product No: EE1068

About this item

NAME AND IDENTIFIERS

CHEMICAL AND PHYSICAL PROPERTIES

Related Compounds

SAFETY AND HAZARDS

Require a Sample Certificate of Analysis (COA) ?