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Product No: EC0505

2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole(Lansoprazole), 98%

Name: 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole(Lansoprazole)
Brand: Chempure

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CAS Number

103577-45-3

Molecular Weight

369.36

Formula

C16H14F3N3O2S

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IUPAC name	2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole
canonical smiles	CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F
inchi	InChI=1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
inchi key	MJIHNNLFOKEZEW-UHFFFAOYSA-N
molecular formula	C16H14F3N3O2S
synonyms	lansoprazole 103577-45-3 Prevacid Limpidex Agopton
Compound Description	Lansoprazole is a member of benzimidazoles, a member of pyridines and a sulfoxide. It has a role as an EC 3.6.3.10 /K-exchanging ATPase) inhibitor and an anti-ulcer drug. Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux disease along with other pathologies caused by excessive acid secretion. Lansoprazole is a Proton Pump Inhibitor. The mechanism of action of lansoprazole is as a Proton Pump Inhibitor. The physiologic effect of lansoprazole is by means of Inhibition Gastric Acid Secretion. Lansoprazole is a proton pump inhibitor and a potent inhibitor of gastric acidity which is widely used in the therapy of gastroesophageal reflux and peptic ulcer disease. Dexlansoprazole is an isomer of lansoprazole that has a similar spectrum of activity and toxicities. Lansoprazole therapy is associated with a low rate of transient and asymptomatic serum aminotransferase elevations and is a reported, but very rare cause of clinically apparent liver injury. Lansoprazole is a substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. Lansoprazole prodrug is converted to an active sulfonamide derivative in the acidic environment of the gastric parietal cell; the sulfonamide derivative binds to the gastric proton pump H+/K+ ATPase and forms a stable disulfide bond with the sulfhydryl group near the potassium-binding site on the luminal side, resulting in inactivation of the ATPase and a reduction in gastric acid secretion. This agent does not have anticholinergic or histamine H2 -receptor antagonistic properties. A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H-K-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of - and -isomers. See also: Lansoprazole; Naproxen ; Amoxicillin; clarithromycin; lansoprazole .

Computed Properties

Molecular Weight:	369.4 g/mol
XLogP3:	2.8
Hydrogen Bond Donor Count:	1
Hydrogen Bond Acceptor Count:	8
Rotatable Bond Count:	5
Exact Mass:	369.07588236 g/mol
Monoisotopic Mass:	369.07588236 g/mol
Topological Polar Surface Area:	87.1 Å²
Heavy Atom Count:	25
Formal Charge:	0
Complexity:	480
Isotope Atom Count:	0
Defined Atom Stereocenter Count:	0
Undefined Atom Stereocenter Count:	1
Defined Bond Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
Covalently-Bonded Unit Count:	1
Compound Is Canonicalized:	Yes

Related Compounds

Omeprazole

Rabeprazole

Lansoprazole

Esomeprazole

Rabeprazole Sodium

(r)-Omeprazole

Dexlansoprazole

Omeprazole sulfone

Lansoprazole sulfide

Rabeprazole thioether

5-O-Desmethyl Omeprazole

Lansoprazole Sulfone

(-)-Pantoprazole

1H-Benzimidazole, 2-(((5-phenyl-1,3,4-oxadiazol-2-yl)thio)methyl)-

2-((2-Dimethylaminobenzyl)sulfinyl)benzimidazole

hazard signal	Warning
hazard classes and categories	Skin Irrit. 2 (97.04%) Eye Irrit. 2 (97.04%) STOT SE 3 (100%) Skin Irrit. 2 (100%) Eye Irrit. 2 (100%)
precautionary statement codes	P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
hazard statements	H315 (97.04%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (97.04%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

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Documentation

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CAS #

*This document is like a lab demo—an example Certificate of Analysis (COA) that showcases what a COA looks like but may not match the latest batch in all its glory. Think of it as a chemistry experiment: close, but not quite the final reaction!

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About this item

IUPAC name	2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole
canonical smiles	CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F
inchi	InChI=1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
inchi key	MJIHNNLFOKEZEW-UHFFFAOYSA-N
molecular formula	C16H14F3N3O2S
synonyms	lansoprazole 103577-45-3 Prevacid Limpidex Agopton
Compound Description	Lansoprazole is a member of benzimidazoles, a member of pyridines and a sulfoxide. It has a role as an EC 3.6.3.10 /K-exchanging ATPase) inhibitor and an anti-ulcer drug. Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux disease along with other pathologies caused by excessive acid secretion. Lansoprazole is a Proton Pump Inhibitor. The mechanism of action of lansoprazole is as a Proton Pump Inhibitor. The physiologic effect of lansoprazole is by means of Inhibition Gastric Acid Secretion. Lansoprazole is a proton pump inhibitor and a potent inhibitor of gastric acidity which is widely used in the therapy of gastroesophageal reflux and peptic ulcer disease. Dexlansoprazole is an isomer of lansoprazole that has a similar spectrum of activity and toxicities. Lansoprazole therapy is associated with a low rate of transient and asymptomatic serum aminotransferase elevations and is a reported, but very rare cause of clinically apparent liver injury. Lansoprazole is a substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. Lansoprazole prodrug is converted to an active sulfonamide derivative in the acidic environment of the gastric parietal cell; the sulfonamide derivative binds to the gastric proton pump H+/K+ ATPase and forms a stable disulfide bond with the sulfhydryl group near the potassium-binding site on the luminal side, resulting in inactivation of the ATPase and a reduction in gastric acid secretion. This agent does not have anticholinergic or histamine H2 -receptor antagonistic properties. A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H-K-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of - and -isomers. See also: Lansoprazole; Naproxen ; Amoxicillin; clarithromycin; lansoprazole .

Computed Properties

Molecular Weight:	369.4 g/mol
XLogP3:	2.8
Hydrogen Bond Donor Count:	1
Hydrogen Bond Acceptor Count:	8
Rotatable Bond Count:	5
Exact Mass:	369.07588236 g/mol
Monoisotopic Mass:	369.07588236 g/mol
Topological Polar Surface Area:	87.1 Å²
Heavy Atom Count:	25
Formal Charge:	0
Complexity:	480
Isotope Atom Count:	0
Defined Atom Stereocenter Count:	0
Undefined Atom Stereocenter Count:	1
Defined Bond Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
Covalently-Bonded Unit Count:	1
Compound Is Canonicalized:	Yes

Related Compounds

Omeprazole

Rabeprazole

Lansoprazole

Esomeprazole

Rabeprazole Sodium

(r)-Omeprazole

Dexlansoprazole

Omeprazole sulfone

Lansoprazole sulfide

Rabeprazole thioether

5-O-Desmethyl Omeprazole

Lansoprazole Sulfone

(-)-Pantoprazole

1H-Benzimidazole, 2-(((5-phenyl-1,3,4-oxadiazol-2-yl)thio)methyl)-

2-((2-Dimethylaminobenzyl)sulfinyl)benzimidazole

hazard signal	Warning
hazard classes and categories	Skin Irrit. 2 (97.04%) Eye Irrit. 2 (97.04%) STOT SE 3 (100%) Skin Irrit. 2 (100%) Eye Irrit. 2 (100%)
precautionary statement codes	P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
hazard statements	H315 (97.04%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (97.04%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Product No: EC0505

2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole(Lansoprazole), 98%

Product No: EC0505

About this item

NAME AND IDENTIFIERS

CHEMICAL AND PHYSICAL PROPERTIES

Related Compounds

SAFETY AND HAZARDS

About this item

Documentation

Certificate of Analysis

Require a Sample Certificate of Analysis (COA) ?

Reviews

Product No: EC0505

About this item

NAME AND IDENTIFIERS

CHEMICAL AND PHYSICAL PROPERTIES

Related Compounds

SAFETY AND HAZARDS

Require a Sample Certificate of Analysis (COA) ?