| precautionary statement codes | P262, P264, P270, P273, P280, P301+P316, P302+P352, P316, P321, P330, P361+P364, P391, P405, and P501 |
| hazards summary | May be absorbed through skin. A cholinesterase inhibitor. In an epidemic involving 19 sugar cane workers, the route of exposure appeared to be inhalation or skin absorption (possibly both). Animal feeding studies showed depression of cholinesterase activity but no gross or microscopic pathology. A highly toxic cholinesterase inhibitor (estimated lethal oral dose of 0.6 g for 70 kg person). Effects in a three-generation feeding study with rats at 20 ppm include reduced pup weight, increase in stillbirths, and fewer pups alive at weaning. Examination of stillborn pups was negative for teratogenicity. Effects in a 2 year feeding study with rats at the highest dose level (80 ppm) include an increase in adrenal weight. No increase in incidence of neoplasm was observed. The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. |
