| hazards summary | 1,2,3-Trichloropropane is a synthetic chemical that is also known as allyl trichloride, glycerol trichlorohydrin, and trichlorohydrin. It is a colorless, heavy liquid with a sweet but strong odor. It evaporates very quickly and small amounts dissolve in water. It is mainly used to make other chemicals. Some of it is also used as an industrial solvent, paint and varnish remover, and cleaning and degreasing agent. Very little information is available on the amounts manufactured and the specific uses.Mice have hepatic damage and die after exposure to 5000 ppm for 20 minutes. Rats and guinea pigs have CNS depression after exposures to 800, 2100, or 5000 ppm for 30 minutes. Workers complained of unpleasant odor and irritation of the eyes and throat at 100 ppm. TLV Basis is cancer. A skin, eye, and respiratory tract irritant. May cause liver and kidney injury. Inhalation of high concentrations can cause CNS depression. The major hazards encountered in the use and handling of 1,2,3-trichloropropane stem from its toxicologic properties. Toxic by inhalation and dermal contact, exposure to this colorless to straw colored acrid smelling liquid may occur from its use as a crosslinking agent in the synthesis of polysulfides, in the synthesis of hexafluoropropylene, as a paint and varnish remover, solvent and degreasing agent. Effects from exposure may include eye and throat irritation. The ACGIH TLV has been set at a TWA of 10 ppm. OSHA has set a PEL of 10 ppm (TWA) to become effective December 31, 1992. Local exhaust ventilation should be used to control exposure. However, in activities where over exposure may occur, wear a self-contained breathing apparatus and personal protective clothing, including gloves, boots and bands around the legs and arms, so that no skin surface is exposed. If contact should occur, wash immediately with soap and remove nonimpervious clothing if contaminated. 1,2,3-Trichloropropane must be moderately heated before ignition will occur (flashpoint: 180 °F open cup). For fires involving 1,2,3-trichloropropane, extinguish with dry chemical, or water (as a blanket, spray, or mist). 1,2,3-Trichloropropane should be stored in a cool, well ventilated place, out of direct rays of the sun, and away from flames, sparks, active metals, strong caustics, and strong oxidizers. For spills of 1,2,3-trichloropropane, first ventilate the area, then absorb the spill with vermiculite, dry sand, or earth, and collect for reclamation disposal, or incineration. Before implementing land disposal of waste 1,2,3-trichloropropane, consult with environmental regulatory agencies for guidance. |