| IUPAC name | 2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid |
| canonical smiles | C1=NC(=C2C(=N1)N(C=N2)CCOCP(=O)(O)O)N |
| inchi | InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16) |
| inchi key | SUPKOOSCJHTBAH-UHFFFAOYSA-N |
| molecular formula | C8H12N5O4P |
| synonyms | ADEFOVIR106941-25-7PMEA((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid9-(2-Phosphonylmethoxyethyl)adenine |
| Compound Description | Adefovir is a member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis ester prodrug is used to treat chronic hepatitis B viral infection. It has a role as a HIV-1 reverse transcriptase inhibitor, a drug metabolite, an antiviral drug, a nephrotoxic agent and a DNA synthesis inhibitor. It is a member of 6-aminopurines, an ether and a member of phosphonic acids. It is functionally related to an adenine. It is a conjugate acid of an adefovir.Adefovir is a Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of adefovir is as a Nucleoside Reverse Transcriptase Inhibitor.Adefovir dipivoxil is an acyclic nucleotide analogue of adenosine used either alone or in combination with other agents as therapy of chronic hepatitis B. Adefovir does not appear to be a significant cause of drug induced liver injury, but initiation of therapy and sudden withdrawal of therapy can induce a transient exacerbation of the underlying hepatitis B.Adefovir is a natural product found in Apis cerana with data available.Adefovir is a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against hepatitis B virus , herpes virus, and human immunodeficiency virus .See also: Adefovir Dipivoxil . |
