| IUPAC name | 2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-1H-purin-6-one |
| canonical smiles | C1=NC2=C(N1COC(CO)CO)N=C(NC2=O)N |
| inchi | InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17) |
| inchi key | IRSCQMHQWWYFCW-UHFFFAOYSA-N |
| molecular formula | C9H13N5O4 |
| synonyms | ganciclovir82410-32-0CytoveneGancyclovirVitrasert |
| Compound Description | Ganciclovir is an oxopurine that is guanine substituted by a [oxy]methyl group at position 9. Ganciclovir is an antiviral drug used to treat or prevent AIDS-related cytomegalovirus infections. It has a role as an antiviral drug and an antiinfective agent. It is an oxopurine and a member of 2-aminopurines. It is functionally related to a guanine.Ganciclovir is an antiviral prescription medicine approved by the U.S. Food and Drug Administration for the treatment of cytomegalovirus retinitis in adults who are immunocompromised, including individuals with AIDS. Ganciclovir is also FDA-approved for the prevention of CMV disease in recipients of organ transplants who are at risk for CMV diseases.CMV diseases, including CMV retinitis, can be opportunistic infections of HIV.An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.Ganciclovir is a Cytomegalovirus Nucleoside Analog DNA Polymerase Inhibitor and Nucleoside Analog Antiviral. The mechanism of action of ganciclovir is as a DNA Polymerase Inhibitor.Ganciclovir is a natural product found in Acremonium persicinum and Homo sapiens with data available.Ganciclovir is a synthetic guanine derivative with antiviral activity. As the active metabolite of ganciclovir, ganciclovir-5-triphosphate appears to inhibit viral DNA synthesis by competitive inhibition of viral DNA polymerases and incorporation into viral DNA, resulting in eventual termination of viral DNA elongation.An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. |
