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Product No: DT8344

Dexmedetomidine hydrochloride, min.98% (HPLC)

Name: Dexmedetomidine hydrochloride
Brand: Chempure

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CAS Number

145108-58-3

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About this item

IUPAC name	5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole;hydrochloride
canonical smiles	CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C.Cl
inchi	InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/m0./s1
inchi key	VPNGEIHDPSLNMU-MERQFXBCSA-N
molecular formula	C13H17ClN2
synonyms	Dexmedetomidine hydrochloride 145108-58-3 Dexmedetomidine HCL Precedex Dexdomitor
Compound Description	Dexmedetomidine hydrochloride is a medetomidine hydrochloride. It has a role as a sedative. It contains a dexmedetomidine. It is an enantiomer of a levomedetomidine hydrochloride. Dexmedetomidine Hydrochloride is the hydrochloride salt form of dexmedetomidine, an imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative activities. Dexmedetomidine selectively binds to and activates presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibits sympathetic activity, thereby leading to analgesia, sedation and anxiolysis. An imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely related to MEDETOMIDINE, which is the racemic form of this compound.

Computed Properties

Molecular Weight:	236.74 g/mol
Hydrogen Bond Donor Count:	2
Hydrogen Bond Acceptor Count:	1
Rotatable Bond Count:	2
Exact Mass:	236.1080262 g/mol
Monoisotopic Mass:	236.1080262 g/mol
Topological Polar Surface Area:	28.7 Å²
Heavy Atom Count:	16
Formal Charge:	0
Complexity:	205
Isotope Atom Count:	0
Defined Atom Stereocenter Count:	1
Undefined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
Covalently-Bonded Unit Count:	2
Compound Is Canonicalized:	Yes

Related Compounds

Dexmedetomidine

Medetomidine

Dexmedetomidine Hydrochloride

Medetomidine Hydrochloride

Detomidine Hydrochloride

Atipamezole

Detomidine

4-Benzyl-1H-imidazole

Atipamezole Hydrochloride

5-(1-naphthalen-1-ylethyl)-1H-imidazole

Methylhistaprodifen

Histaprodifen

4-(1-(1-Naphthyl)ethyl)imidazole

4-(8-Phenyl-oct-3-ynyl)-1H-imidazole

4-(4-phenylbutyl)-3H-imidazole

hazard signal	Warning
hazard classes and categories	Acute Tox. 4 (93.18%) Skin Irrit. 2 (93.18%) Eye Irrit. 2 (95.45%) STOT SE 3 (100%)
precautionary statement codes	P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
hazard statements	H302 (93.18%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (93.18%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (95.45%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

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Documentation

Certificate of Analysis

Lot Number

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CAS #

*This document is like a lab demo—an example Certificate of Analysis (COA) that showcases what a COA looks like but may not match the latest batch in all its glory. Think of it as a chemistry experiment: close, but not quite the final reaction!

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About this item

IUPAC name	5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole;hydrochloride
canonical smiles	CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C.Cl
inchi	InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/m0./s1
inchi key	VPNGEIHDPSLNMU-MERQFXBCSA-N
molecular formula	C13H17ClN2
synonyms	Dexmedetomidine hydrochloride 145108-58-3 Dexmedetomidine HCL Precedex Dexdomitor
Compound Description	Dexmedetomidine hydrochloride is a medetomidine hydrochloride. It has a role as a sedative. It contains a dexmedetomidine. It is an enantiomer of a levomedetomidine hydrochloride. Dexmedetomidine Hydrochloride is the hydrochloride salt form of dexmedetomidine, an imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative activities. Dexmedetomidine selectively binds to and activates presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibits sympathetic activity, thereby leading to analgesia, sedation and anxiolysis. An imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely related to MEDETOMIDINE, which is the racemic form of this compound.

Computed Properties

Molecular Weight:	236.74 g/mol
Hydrogen Bond Donor Count:	2
Hydrogen Bond Acceptor Count:	1
Rotatable Bond Count:	2
Exact Mass:	236.1080262 g/mol
Monoisotopic Mass:	236.1080262 g/mol
Topological Polar Surface Area:	28.7 Å²
Heavy Atom Count:	16
Formal Charge:	0
Complexity:	205
Isotope Atom Count:	0
Defined Atom Stereocenter Count:	1
Undefined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
Covalently-Bonded Unit Count:	2
Compound Is Canonicalized:	Yes

Related Compounds

Dexmedetomidine

Medetomidine

Dexmedetomidine Hydrochloride

Medetomidine Hydrochloride

Detomidine Hydrochloride

Atipamezole

Detomidine

4-Benzyl-1H-imidazole

Atipamezole Hydrochloride

5-(1-naphthalen-1-ylethyl)-1H-imidazole

Methylhistaprodifen

Histaprodifen

4-(1-(1-Naphthyl)ethyl)imidazole

4-(8-Phenyl-oct-3-ynyl)-1H-imidazole

4-(4-phenylbutyl)-3H-imidazole

hazard signal	Warning
hazard classes and categories	Acute Tox. 4 (93.18%) Skin Irrit. 2 (93.18%) Eye Irrit. 2 (95.45%) STOT SE 3 (100%)
precautionary statement codes	P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
hazard statements	H302 (93.18%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (93.18%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (95.45%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Product No: DT8344

Dexmedetomidine hydrochloride, min.98% (HPLC)

Product No: DT8344

About this item

NAME AND IDENTIFIERS

CHEMICAL AND PHYSICAL PROPERTIES

Related Compounds

SAFETY AND HAZARDS

About this item

Documentation

Certificate of Analysis

Require a Sample Certificate of Analysis (COA) ?

Reviews

Product No: DT8344

About this item

NAME AND IDENTIFIERS

CHEMICAL AND PHYSICAL PROPERTIES

Related Compounds

SAFETY AND HAZARDS

Require a Sample Certificate of Analysis (COA) ?