| IUPAC name | (2R,3R,5S)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolan-3-ol |
| inchi | InChI=1S/C10H13N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h3-6,10,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,10+/m0/s1 |
| inchi key | OFEZSBMBBKLLBJ-BAJZRUMYSA-N |
| molecular formula | C10H13N5O3 |
| synonyms | Cordycepin3'-Deoxyadenosine73-03-0Cordycepine9-Cordyceposidoadenine |
| Compound Description | Cordycepin is a 3'-deoxyribonucleoside and a member of adenosines. It has a role as an antimetabolite and a nucleoside antibiotic.Cordycepin has been used in trials studying the treatment of Leukemia.Cordycepin has been reported in Cordyceps militaris, Streptomyces sparsogenes, and other organisms with data available.Cordycepin is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic, antioxidant, and anti-inflammatory activities. Cordycepin is an inhibitor of polyadenylation, activates AMP-activated protein kinase and reduces mammalian target of rapamycin signaling, which may result in both the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine kinase belonging to the phosphatidylinositol 3-kinase -related kinase family, plays an important role in the PI3K/AKT/mTOR signaling pathway that regulates cell growth and proliferation, and its expression or activity is frequently dysregulated in human cancers.CORDYCEPIN is a small molecule drug with a maximum clinical trial phase of I and has 1 investigational indication. |
