| IUPAC name | (1R,9S)-7,11-diazatricyclo[7.3.1.02,7]trideca-2,4-dien-6-one |
| inchi | InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9+/m0/s1 |
| inchi key | ANJTVLIZGCUXLD-DTWKUNHWSA-N |
| molecular formula | C11H14N2O |
| synonyms | CYTISINE485-35-8BaptitoxineSophorineCytisinicline |
| Compound Description | Cytisine is an organic heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae family. An acetylcholine agonist, it is widely used throughout Eastern Europe as an aid to giving up smoking. It has a role as a nicotinic acetylcholine receptor agonist, a phytotoxin and a plant metabolite. It is an alkaloid, an organic heterotricyclic compound, a secondary amino compound, a lactam and a bridged compound.Cytisine is an alkaloid naturally derived from the Fabaceae family of plants including the genera Laburnum and Cytisus. Recent studies have shown it to be a more effective and significantly more affordable smoking cessation treatment than nicotine replacement therapy. Also known as baptitoxine or sophorine, cytisine has been used as a smoking cessation treatment since 1964, and is relatively unknown in regions outside of central and Eastern Europe. Cytisine is a partial nicotinic acetylcholine agonist with a half-life of 4.8 hours. Recent Phase III clinical trials using Tabex have shown similar efficacy to varenicline, but at a fraction of the cost.Cytisine has been reported in Aphis cytisorum, Maackia tenuifolia, and other organisms with data available.CYTISINICLINE is a small molecule drug with a maximum clinical trial phase of III and has 3 investigational indications.See also: Cytisus scoparius flowering top ; Thermopsis lanceolata whole . |
