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Product No: DT7916

Amikacin disulfate salt, min.97% (NMR)

Name: Amikacin disulfate salt
Brand: Chempure
Rating: 4 (1 reviews)

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CAS Number

39831-55-5

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IUPAC name	(2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide;sulfuric acid
canonical smiles	C1C(C(C(C(C1NC(=O)C(CCN)O)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(C(C(C(O3)CN)O)O)O)N.OS(=O)(=O)O.OS(=O)(=O)O
inchi	InChI=1S/C22H43N5O13.2H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;21-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);2(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;;/m0../s1
inchi key	FXKSEJFHKVNEFI-GCZBSULCSA-N
molecular formula	C22H47N5O21S2
synonyms	AMIKACIN SULFATE Amikacin disulfate 39831-55-5 Amikin Pierami
Compound Description	Amikacin disulfate is an aminoglycoside sulfate salt obtained by combining amikacin with two molar equivalents of sulfuric acid. It has a role as an antibacterial drug, an antimicrobial agent and a nephrotoxin. It contains an amikacin. Amikacin Sulfate is the sulfate salt of amikacin, a broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically in contact with 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria. A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.

Computed Properties

Molecular Weight:	781.8 g/mol
Hydrogen Bond Donor Count:	17
Hydrogen Bond Acceptor Count:	25
Rotatable Bond Count:	10
Exact Mass:	781.22049587 g/mol
Monoisotopic Mass:	781.22049587 g/mol
Topological Polar Surface Area:	498 Å²
Heavy Atom Count:	50
Formal Charge:	0
Complexity:	900
Isotope Atom Count:	0
Defined Atom Stereocenter Count:	16
Undefined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
Covalently-Bonded Unit Count:	3
Compound Is Canonicalized:	Yes

Related Compounds

Amikacin

Arbekacin

Amikacin sulfate

Amikacin disulfate

(2R)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide;sulfuric acid

butirosin A

Biodacyn

CID 73652147

4-amino-N-[(1R,2S,3S,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide;sulfuric acid

(2S)-4-amino-N-[(1R,2S,3S,4S,5S)-5-amino-2-[(2S,3S,4S,5S,6S)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3S,4S,5S,6S)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide;sulfuric acid

Arbekacin sulfate

Isepamicin sulfate

Butirosin B

Ambutyrosin

Amikacin sulfate(5:9)

hazard signal	Danger
hazard classes and categories	Skin Sens. 1B (95.12%) Eye Dam. 1 (64.63%) STOT RE 1 (64.63%)
precautionary statement codes	P260, P261, P264, P264+P265, P270, P272, P280, P302+P352, P305+P354+P338, P317, P319, P321, P333+P317, P362+P364, and P501
hazard statements	H317 (95.12%): May cause an allergic skin reaction [Warning Sensitization, Skin] H318 (64.63%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H372 (64.63%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

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Documentation

Certificate of Analysis

Lot Number

Require a Sample Certificate of Analysis (COA) ?

CAS #

*This document is like a lab demo—an example Certificate of Analysis (COA) that showcases what a COA looks like but may not match the latest batch in all its glory. Think of it as a chemistry experiment: close, but not quite the final reaction!

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About this item

IUPAC name	(2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide;sulfuric acid
canonical smiles	C1C(C(C(C(C1NC(=O)C(CCN)O)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(C(C(C(O3)CN)O)O)O)N.OS(=O)(=O)O.OS(=O)(=O)O
inchi	InChI=1S/C22H43N5O13.2H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;21-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);2(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;;/m0../s1
inchi key	FXKSEJFHKVNEFI-GCZBSULCSA-N
molecular formula	C22H47N5O21S2
synonyms	AMIKACIN SULFATE Amikacin disulfate 39831-55-5 Amikin Pierami
Compound Description	Amikacin disulfate is an aminoglycoside sulfate salt obtained by combining amikacin with two molar equivalents of sulfuric acid. It has a role as an antibacterial drug, an antimicrobial agent and a nephrotoxin. It contains an amikacin. Amikacin Sulfate is the sulfate salt of amikacin, a broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically in contact with 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria. A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.

Computed Properties

Molecular Weight:	781.8 g/mol
Hydrogen Bond Donor Count:	17
Hydrogen Bond Acceptor Count:	25
Rotatable Bond Count:	10
Exact Mass:	781.22049587 g/mol
Monoisotopic Mass:	781.22049587 g/mol
Topological Polar Surface Area:	498 Å²
Heavy Atom Count:	50
Formal Charge:	0
Complexity:	900
Isotope Atom Count:	0
Defined Atom Stereocenter Count:	16
Undefined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
Covalently-Bonded Unit Count:	3
Compound Is Canonicalized:	Yes

Related Compounds

Amikacin

Arbekacin

Amikacin sulfate

Amikacin disulfate

butirosin A

Biodacyn

CID 73652147

Arbekacin sulfate

Isepamicin sulfate

Butirosin B

Ambutyrosin

Amikacin sulfate(5:9)

hazard signal	Danger
hazard classes and categories	Skin Sens. 1B (95.12%) Eye Dam. 1 (64.63%) STOT RE 1 (64.63%)
precautionary statement codes	P260, P261, P264, P264+P265, P270, P272, P280, P302+P352, P305+P354+P338, P317, P319, P321, P333+P317, P362+P364, and P501
hazard statements	H317 (95.12%): May cause an allergic skin reaction [Warning Sensitization, Skin] H318 (64.63%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H372 (64.63%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

Product No: DT7916

Amikacin disulfate salt, min.97% (NMR)

Product No: DT7916

About this item

NAME AND IDENTIFIERS

CHEMICAL AND PHYSICAL PROPERTIES

Related Compounds

SAFETY AND HAZARDS

About this item

Documentation

Certificate of Analysis

Require a Sample Certificate of Analysis (COA) ?

Reviews

Product No: DT7916

About this item

NAME AND IDENTIFIERS

CHEMICAL AND PHYSICAL PROPERTIES

Related Compounds

SAFETY AND HAZARDS

Require a Sample Certificate of Analysis (COA) ?