| IUPAC name | (2S)-2-amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-methylsulfonio]butanoate |
| inchi | InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27?/m0/s1 |
| inchi key | MEFKEPWMEQBLKI-AIRLBKTGSA-N |
| molecular formula | C15H22N6O5S |
| synonyms | S-adenosyl-L-methionineAdemetionineS-adenosylmethionine29908-03-0AdoMet |
| Compound Description | S-adenosyl-L-methioninate is a sulfonium betaine that is a conjugate base of S-adenosyl-L-methionine obtained by the deprotonation of the carboxy group. It has a role as a human metabolite. It is functionally related to a L-methioninate. It is a conjugate base of a S-adenosyl-L-methionine.Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. S-Adenosylmethionine is a metabolite found in or produced by Escherichia coli .S-adenosylmethionine has been reported in Homo sapiens and Pisum sativum with data available.S-Adenosylmethionine is a nutritional supplement that is synthesized from adenosine triphosphate and the amino acid methionine by the endogenous essential enzyme methionine adenosyltransferase , with potential antineoplastic activity. Upon administration, S-adenosylmethionine acts as a methyl donor for various transmethylation reactions. In cancer cells, this agent induces the methylation of tumor promoting genes, reverses DNA hypomethylation, and leads to the suppression of oncogene transcription. This induces apoptosis in and inhibits proliferation of susceptible tumor cells.Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. See also: S-Adenosyl-L-methionine Disulfate Tosylate ; S-Adenosylmethionine chloride . |
