| IUPAC name | (7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one |
| inchi | InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1 |
| inchi key | NNJPGOLRFBJNIW-HNNXBMFYSA-N |
| molecular formula | C21H25NO5 |
| synonyms | Demecolcinecolcemid477-30-5ColchamineDemecolcin |
| Compound Description | -demecolcine is a secondary amino compound that is -colchicine in which the N-acetyl group is replaced by an N-methyl group. Isolable from the autumn crocus, Colchicum autumnale, it is less toxic than colchicine and is used as an antineoplastic. It has a role as an antineoplastic agent and a microtubule-destabilising agent. It is an alkaloid and a secondary amino compound.Demecolcine has been reported in Colchicum arenarium, Gagea lutea, and other organisms with data available.Demecolcine is a colchicine analog with potential antimitotic and antineoplastic activities. Demecolcine acid binds to the colchicine-binding site of tubulin, inhibiting its polymerization into microtubules, causing cell cycle arrest at metaphase and preventing cell division.DEMECOLCINE is a small molecule drug with a maximum clinical trial phase of II and has 1 investigational indication.An alkaloid isolated from Colchicum autumnale L. and used as an antineoplastic. |
