| IUPAC name | N'-hydroxy-N-pyridin-3-yloctanediamide |
| inchi | InChI=1S/C13H19N3O3/c17-12(15-11-6-5-9-14-10-11)7-3-1-2-4-8-13(18)16-19/h5-6,9-10,19H,1-4,7-8H2,(H,15,17)(H,16,18) |
| inchi key | PTJGLFIIZFVFJV-UHFFFAOYSA-N |
| molecular formula | C13H19N3O3 |
| synonyms | pyroxamide382180-17-8N1-hydroxy-N8-(pyridin-3-yl)octanediamideN-Hydroxy-N'-3-pyridinyloctanediamideN'-hydroxy-N-pyridin-3-yloctanediamide |
| Compound Description | N'-hydroxy-N-octanediamide is an aromatic amide.Pyroxamide has been used in trials studying the treatment of Leukemia, Lymphoma, Small Intestine Cancer, Precancerous Condition, and Myelodysplastic Syndromes, among others.Pyroxamide is a synthetic derivative of hydroxamic acid with antineoplastic properties, Pyroxamide inhibits histone deacetylases involved in transcription; induces hyperacetylation of core histones, modulating chromatin structure and affecting transcription of some genes that inhibit tumor growth; and induces growth arrest and apoptosis. Pyroxamide is used in clinical studies for cancer chemotherapy. |
