| IUPAC name | 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid |
| canonical smiles | CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2 |
| inchi | InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23) |
| inchi key | MAEIEVLCKWDQJH-UHFFFAOYSA-N |
| molecular formula | C17H20N2O5S |
| synonyms | bumetanide28395-03-13-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acidBumexBurinex |
| Compound Description | Bumetanide is a member of the class of benzoic acids that is 4-phenoxybenzoic acid in which the hydrogens ortho to the phenoxy group are substituted by butylamino and sulfamoyl groups. Bumetanide is a diuretic, and is used for treatment of oedema associated with congestive heart failure, hepatic and renal disease. It has a role as a diuretic and an EC 3.6.3.49 inhibitor. It is a sulfonamide, an amino acid and a member of benzoic acids.Bumetanide is a sulfamyl diuretic.Bumetanide is a Loop Diuretic. The physiologic effect of bumetanide is by means of Increased Diuresis at Loop of Henle.Bumetanide is a potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter , thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates.A sulfamyl diuretic. |
