(2Z)-but-2-enedioic acid, 5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione, 95%

Name: (2Z)-but-2-enedioic acid, 5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione
Brand: Chempure

()

CAS Number

155141-29-0

Total BLR Stock

Bulk Quote

Pack Size	Qty	Lead Time	Price	Quantity

About this item

IUPAC name	(Z)-but-2-enedioic acid;5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
inchi	InChI=1S/C18H19N3O3S.C4H4O4/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15;5-3(6)1-2-4(7)8/h2-9,15H,10-12H2,1H3,(H,20,22,23);1-2H,(H,5,6)(H,7,8)/b;2-1-
inchi key	SUFUKZSWUHZXAV-BTJKTKAUSA-N
molecular formula	C22H23N3O7S
synonyms	Rosiglitazone maleate 155141-29-0 Avandia Rosiglitazone XR Rosiglitazone (maleate)
Compound Description	Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Rosiglitazone activates peroxisome proliferator-activated receptor gamma , a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. ROSIGLITAZONE MALEATE is a small molecule drug with a maximum clinical trial phase of IV that was first approved in 1999 and is indicated for diabetes mellitus and type 2 diabetes mellitus and has 10 investigational indications. It was withdrawn in at least one region. This drug has a black box warning from the FDA. A thiazolidinedione that functions as a selective agonist for PPAR GAMMA. It improves INSULIN SENSITIVITY in adipose tissue, skeletal muscle, and the liver of patients with TYPE 2 DIABETES MELLITUS. See also: Rosiglitazone ; Glimepiride; Rosiglitazone Maleate ; Metformin Hydrochloride; Rosiglitazone Maleate .

Computed Properties

Molecular Weight:	473.5 g/mol
Hydrogen Bond Donor Count:	3
Hydrogen Bond Acceptor Count:	10
Rotatable Bond Count:	9
Exact Mass:	473.12567125 g/mol
Monoisotopic Mass:	473.12567125 g/mol
Topological Polar Surface Area:	171 Å²
Heavy Atom Count:	33
Formal Charge:	0
Complexity:	588
Isotope Atom Count:	0
Defined Atom Stereocenter Count:	0
Undefined Atom Stereocenter Count:	1
Defined Bond Stereocenter Count:	1
Undefined Bond Stereocenter Count:	0
Covalently-Bonded Unit Count:	2
Compound Is Canonicalized:	Yes

hazard signal	Warning
hazard classes and categories	Eye Irrit. 2 (60%) Repr. 2 (40%) Aquatic Chronic 2 (60%)
precautionary statement codes	P203, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501
hazard statements	H302 (20%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (20%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (60%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (20%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] H361 (40%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] H411 (60%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

;

About this item

Documentation

Certificate of Analysis

Lot Number

Require a Sample Certificate of Analysis (COA) ?

CAS #

*This document is like a lab demo—an example Certificate of Analysis (COA) that showcases what a COA looks like but may not match the latest batch in all its glory. Think of it as a chemistry experiment: close, but not quite the final reaction!

Reviews

About this item

IUPAC name	(Z)-but-2-enedioic acid;5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
inchi	InChI=1S/C18H19N3O3S.C4H4O4/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15;5-3(6)1-2-4(7)8/h2-9,15H,10-12H2,1H3,(H,20,22,23);1-2H,(H,5,6)(H,7,8)/b;2-1-
inchi key	SUFUKZSWUHZXAV-BTJKTKAUSA-N
molecular formula	C22H23N3O7S
synonyms	Rosiglitazone maleate 155141-29-0 Avandia Rosiglitazone XR Rosiglitazone (maleate)
Compound Description	Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Rosiglitazone activates peroxisome proliferator-activated receptor gamma , a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. ROSIGLITAZONE MALEATE is a small molecule drug with a maximum clinical trial phase of IV that was first approved in 1999 and is indicated for diabetes mellitus and type 2 diabetes mellitus and has 10 investigational indications. It was withdrawn in at least one region. This drug has a black box warning from the FDA. A thiazolidinedione that functions as a selective agonist for PPAR GAMMA. It improves INSULIN SENSITIVITY in adipose tissue, skeletal muscle, and the liver of patients with TYPE 2 DIABETES MELLITUS. See also: Rosiglitazone ; Glimepiride; Rosiglitazone Maleate ; Metformin Hydrochloride; Rosiglitazone Maleate .

Computed Properties

Molecular Weight:	473.5 g/mol
Hydrogen Bond Donor Count:	3
Hydrogen Bond Acceptor Count:	10
Rotatable Bond Count:	9
Exact Mass:	473.12567125 g/mol
Monoisotopic Mass:	473.12567125 g/mol
Topological Polar Surface Area:	171 Å²
Heavy Atom Count:	33
Formal Charge:	0
Complexity:	588
Isotope Atom Count:	0
Defined Atom Stereocenter Count:	0
Undefined Atom Stereocenter Count:	1
Defined Bond Stereocenter Count:	1
Undefined Bond Stereocenter Count:	0
Covalently-Bonded Unit Count:	2
Compound Is Canonicalized:	Yes

hazard signal	Warning
hazard classes and categories	Eye Irrit. 2 (60%) Repr. 2 (40%) Aquatic Chronic 2 (60%)
precautionary statement codes	P203, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501
hazard statements	H302 (20%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (20%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (60%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (20%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] H361 (40%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] H411 (60%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Product No: BL1916

(2Z)-but-2-enedioic acid, 5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione, 95%

Product No: BL1916

About this item

NAME AND IDENTIFIERS

CHEMICAL AND PHYSICAL PROPERTIES

SAFETY AND HAZARDS

About this item

Documentation

Certificate of Analysis

Require a Sample Certificate of Analysis (COA) ?

Reviews

Product No: BL1916

About this item

NAME AND IDENTIFIERS

CHEMICAL AND PHYSICAL PROPERTIES

SAFETY AND HAZARDS

Require a Sample Certificate of Analysis (COA) ?