| IUPAC name | 1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol |
| canonical smiles | CC(C)NCC(COC1=CC=CC2=C1C=CN2)O |
| inchi | InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3 |
| inchi key | JZQKKSLKJUAGIC-UHFFFAOYSA-N |
| molecular formula | C14H20N2O2 |
| synonyms | pindolol13523-86-9ViskenBetapindolPrinodolol |
| Compound Description | Pindolol is a member of the class of indols which is the 2-hydroxy-3-propyl ether derivative of 1H-indol-4-ol. It has a role as a serotonergic antagonist, a beta-adrenergic antagonist, an antihypertensive agent, a vasodilator agent and an antiglaucoma drug. It is a member of indoles and a secondary amine.Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the early 1970s. Pindolol was granted FDA approval on 3 September 1982.Pindolol is a beta-Adrenergic Blocker. The mechanism of action of pindolol is as an Adrenergic beta-Antagonist.Pindolol is a nonselective beta adrenergic receptor blocker that is widely used for the therapy of hypertension and angina pectoris. Pindolol has yet to be convincingly associated with clinically apparent liver injury.Pindolol is an aryloxypropanolamine derivative with antihypertensive property. Pindolol competitively binds to beta-adrenergic receptors, resulting in a decrease in beta-adrenergic activities, i.e., vasodilation, and negative chronotropic and inotropic effects. In addition, this agent blocks serotonin 1A receptors, thereby increasing the available serotonin in the brain. Increased serotonin levels augment the antidepressant action of selective serotonin reuptake inhibitors and monoamine oxidase inhibitors.A moderately lipophilic beta blocker . It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. See also: Hydrochlorothiazide; pindolol . |
