| IUPAC name | (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide |
| canonical smiles | C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N |
| inchi | InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+ |
| inchi key | TUCIOBMMDDOEMM-RIYZIHGNSA-N |
| molecular formula | C17H14N2O3 |
| synonyms | 133550-30-8AG-490Tyrphostin B42Tyrphostin AG 490AG 490 |
| Compound Description | Tyrphostin B42 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of -2-cyano-3-prop-2-enoic acid with the amino group of benzylamine. It has a role as an EC 2.7.10.2 inhibitor, an antioxidant, a STAT3 inhibitor, an anti-inflammatory agent, an apoptosis inducer and a geroprotector. It is an enamide, a monocarboxylic acid amide, a nitrile, a member of catechols and a secondary carboxamide.Tyrphostin B42 is a member of the tyrphostin family of tyrosine kinase inhibitors that inhibits epidermal growth factor receptor, blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death. Inhibits the constitutive activation of STAT-3 DNA binding and IL-2-induced growth of Mycosis fungoides tumor cells. |
