Latanoprost, >98.0%(HPLC)

Name: Latanoprost
Brand: Chempure

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CAS Number

130209-82-4

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IUPAC name	propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
inchi	InChI=1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3-/t21-,22+,23+,24-,25+/m0/s1
inchi key	GGXICVAJURFBLW-CEYXHVGTSA-N
molecular formula	C26H40O5
synonyms	latanoprost 130209-82-4 Xalatan PhXA41 PHXA-41
Compound Description	Latanoprost is a prostaglandin Falpha that is the isopropyl ester prodrug of latanoprost free acid. Used in the treatment of open-angle glaucoma and ocular hypertension. It has a role as an antiglaucoma drug, an antihypertensive agent, an EC 4.2.1.1 inhibitor and a prodrug. It is a prostaglandins Falpha, a triol and an isopropyl ester. It is functionally related to a latanoprost free acid. Latanoprost is a prodrug analog of prostaglandin F2 alpha that is used to treat elevated intraocular pressure . It was initially approved by the FDA in 1998. Latanoprost is the first topical prostaglandin F2 alpha analog used for glaucoma treatment. It has been found to be well-tolerated and its use does not normally result in systemic adverse effects like other drugs used to treat elevated intraocular pressure, such as [Timolol]. Another benefit latanoprost is that it can be administered once a day. Latanoprost is a Prostaglandin Analog. Latanoprost is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure. LATANOPROST is a small molecule drug with a maximum clinical trial phase of IV that was first approved in 1996 and has 4 approved and 2 investigational indications. A prostaglandin F analog used to treat OCULAR HYPERTENSION in patients with GLAUCOMA. See also: Latanoprost; netarsudil dimesylate ; Latanoprost; timolol maleate ; Latanoprost; netarsudil mesylate .

Computed Properties

Molecular Weight:	432.6 g/mol
XLogP3:	4.3
Hydrogen Bond Donor Count:	3
Hydrogen Bond Acceptor Count:	5
Rotatable Bond Count:	14
Exact Mass:	432.28757437 g/mol
Monoisotopic Mass:	432.28757437 g/mol
Topological Polar Surface Area:	87 Å²
Heavy Atom Count:	31
Formal Charge:	0
Complexity:	526
Isotope Atom Count:	0
Defined Atom Stereocenter Count:	5
Undefined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	1
Undefined Bond Stereocenter Count:	0
Covalently-Bonded Unit Count:	1
Compound Is Canonicalized:	Yes

hazard signal	Danger
hazard classes and categories	Acute Tox. 1 (63.9%) Acute Tox. 3 (10.4%) Repr. 2 (61.8%)
precautionary statement codes	P203, P264, P270, P280, P301+P316, P318, P321, P330, P405, and P501
hazard statements	H300 (63.9%): Fatal if swallowed [Danger Acute toxicity, oral] H301 (10.4%): Toxic if swallowed [Danger Acute toxicity, oral] H361 (61.8%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

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IUPAC name	propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
inchi	InChI=1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3-/t21-,22+,23+,24-,25+/m0/s1
inchi key	GGXICVAJURFBLW-CEYXHVGTSA-N
molecular formula	C26H40O5
synonyms	latanoprost 130209-82-4 Xalatan PhXA41 PHXA-41
Compound Description	Latanoprost is a prostaglandin Falpha that is the isopropyl ester prodrug of latanoprost free acid. Used in the treatment of open-angle glaucoma and ocular hypertension. It has a role as an antiglaucoma drug, an antihypertensive agent, an EC 4.2.1.1 inhibitor and a prodrug. It is a prostaglandins Falpha, a triol and an isopropyl ester. It is functionally related to a latanoprost free acid. Latanoprost is a prodrug analog of prostaglandin F2 alpha that is used to treat elevated intraocular pressure . It was initially approved by the FDA in 1998. Latanoprost is the first topical prostaglandin F2 alpha analog used for glaucoma treatment. It has been found to be well-tolerated and its use does not normally result in systemic adverse effects like other drugs used to treat elevated intraocular pressure, such as [Timolol]. Another benefit latanoprost is that it can be administered once a day. Latanoprost is a Prostaglandin Analog. Latanoprost is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure. LATANOPROST is a small molecule drug with a maximum clinical trial phase of IV that was first approved in 1996 and has 4 approved and 2 investigational indications. A prostaglandin F analog used to treat OCULAR HYPERTENSION in patients with GLAUCOMA. See also: Latanoprost; netarsudil dimesylate ; Latanoprost; timolol maleate ; Latanoprost; netarsudil mesylate .

Computed Properties

Molecular Weight:	432.6 g/mol
XLogP3:	4.3
Hydrogen Bond Donor Count:	3
Hydrogen Bond Acceptor Count:	5
Rotatable Bond Count:	14
Exact Mass:	432.28757437 g/mol
Monoisotopic Mass:	432.28757437 g/mol
Topological Polar Surface Area:	87 Å²
Heavy Atom Count:	31
Formal Charge:	0
Complexity:	526
Isotope Atom Count:	0
Defined Atom Stereocenter Count:	5
Undefined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	1
Undefined Bond Stereocenter Count:	0
Covalently-Bonded Unit Count:	1
Compound Is Canonicalized:	Yes

hazard signal	Danger
hazard classes and categories	Acute Tox. 1 (63.9%) Acute Tox. 3 (10.4%) Repr. 2 (61.8%)
precautionary statement codes	P203, P264, P270, P280, P301+P316, P318, P321, P330, P405, and P501
hazard statements	H300 (63.9%): Fatal if swallowed [Danger Acute toxicity, oral] H301 (10.4%): Toxic if swallowed [Danger Acute toxicity, oral] H361 (61.8%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

Product No: AU0822

Latanoprost, >98.0%(HPLC)

Product No: AU0822

About this item

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CHEMICAL AND PHYSICAL PROPERTIES

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Documentation

Certificate of Analysis

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Product No: AU0822

About this item

NAME AND IDENTIFIERS

CHEMICAL AND PHYSICAL PROPERTIES

SAFETY AND HAZARDS

Require a Sample Certificate of Analysis (COA) ?