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*This document is like a lab demo—an example Certificate of Analysis (COA) that showcases what a COA looks like but may not match the latest batch in all its glory. Think of it as a chemistry experiment: close, but not quite the final reaction!
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Bulk Quote| hazards summary | Silica is another name for the chemical compound composed of silicon and oxygen with the chemical formula SiO2, or silicon dioxide. There are many forms of silica. All silica forms are identical in chemical composition, but have different atom arrangements. Silica compounds can be divided into two groups, crystalline (or c-silica) and amorphous silica (a-silica or non-crystalline silica). c-Silica compounds have structures with repeating patterns of silicon and oxygen. a-Silica chemical structures are more randomly linked when compared to c-silica. All forms of silica are odorless solids composed of silicon and oxygen atoms. Silica particles become suspended in air and form non-explosive dusts. Silica may combine with other metallic elements and oxides to form silicates.Silica occurs in both crystalline and amorphous forms. Quartz is the most common crystalline form, and it causes most cases of silicosis. Exposure to crystalline silica (alpha-quartz and cristobalite) is associated with lung fibrosis (silicosis) and increased risk of lung cancer. Classic silicosis is caused by low to moderate silica exposure for 20 years or more. Disabling complications include tuberculosis and progressive massive fibrosis. Diagnosis is made by 1.) history of sufficient exposure. 2.) x-ray findings of silicosis. and 3.) absence of miliary tuberculosis and fungal infections. Open lung biopsy is usually not necessary. The possible association of silica and glomerulonephritis is suggested by animal studies, case-control studies, and multiple case reports. Overall the evidence is still too sparse to be summarized as conclusive, but it seems very probable that silica causes kidney disease. Silica-associated kidney disease was not detected in a study of 4 million death certificates of US workers for the period from 1982 to 1995. While the studies of cohorts exposed to silica found elevated SMRs for renal disease, no clear evidence of a dose-response relationship emerged. Low grade silicosis cannot be excluded in workers with normal chest radiographs (ILO 0/0). In relatively highly exposed construction workers, a sevenfold increased risk of simple (nodular) silicosis was found. Emphysema on HRCT was associated with current or former smokers, but not with exposure, and contributed to reduced diffusion capacity. Airflow limitation was mainly determined by current smoking and was not associated with simple (nodular) silicosis. See Respirable crystalline silica exposure-response evaluation of silicosis morbidity and lung cancer mortality in the German porcelain industry cohort. The absence of an excess mortality from lung cancer does not support the hypothesis of an association between silica exposure and the development of lung cancer, in the absence of silicosis. See Silicosis, simple.Silica, amorphous (7631-86-9) is not classifiable as to carcinogenicity to humans. Documentation and TLV withdrawn in 2006 because of insufficient data. The main problem in assessing the risk of exposure to diatomaceous earth is its varying degree of contamination with crystalline silica. While the natural version usually contains about 1%, up to 60% may be present in flux-calcined amorphous silica. Contains crystalline silica, known to cause occupational silicosis. Causes no skin and mild eye irritation. Not a skin sensitizer. The main problem in assessing the risk of exposure to diatomaceous earth is its varying degree of contamination with crystalline silica. While the natural version usually contains about 1%, up to 60% may be present in flux-calcined amorphous silica. A strong eye irritant. Prolonged or repeated inhalation exposure may cause serious adverse health effects. See Kieselguhr, calcined. See Silica, amorphous and Silica, crystalline. |
