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CAS #
*This document is like a lab demo—an example Certificate of Analysis (COA) that showcases what a COA looks like but may not match the latest batch in all its glory. Think of it as a chemistry experiment: close, but not quite the final reaction!
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Bulk Quote| Monoisotopic Mass: | 23.03472750 g/mol |
| Topological Polar Surface Area: | 1 Ų |
| Heavy Atom Count: | 2 |
| Formal Charge: | 0 |
| Complexity: | 2 |
| Isotope Atom Count: | 0 |
| Defined Atom Stereocenter Count: | 0 |
| Undefined Atom Stereocenter Count: | 0 |
| Defined Bond Stereocenter Count: | 0 |
| Undefined Bond Stereocenter Count: | 0 |
| Covalently-Bonded Unit Count: | 2 |
| Compound Is Canonicalized: | Yes |
| Related Compounds |
| hazard signal | Danger |
| hazard classes and categories | |
| precautionary statement codes | P231+P232, P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P402+P404, P405, and P501 |
| hazard statements | |
| hazards summary | Decomposes in water to form ammonia. Explosive peroxide formed on storage. |
| toxicity summary | IDENTIFICATION AND USE: Lithium amide is a white crystalline powder which is slightly soluble in ethanol, liquid ammonia and insoluble in anhydrous ether, benzene , xylene and toluene. It is used in Claisen condensations; alkylation of nitriles and ketones; synthesis of ethynyl compounds, and acetylenic carbinols. It is used in organic synthesis, including antihistamines and other pharmaceuticals. HUMAN EXPOSURE AND TOXICITY: Lithium amide is a powerful irritant to skin, eyes, and mucous membrane. ANIMAL STUDIES: The most prominent symptoms of acute lithium poisoning in animals when given lithium either by mouth or iv are anorexia, nausea, vomiting, diarrhea and salivation with loss of weight, dehydration and fall of body temperature. Effects on CNS are manifested by muscular weakness, hyperirritability, stupor and convulsions; on the heart by EKG changes with auricular standstill or fibrillation; on the kidneys by oliguria, a rise in blood protein nitrogen and degenerative changes in tubular epithelium. Chronic renal failure was induced by administering lithium orally to 14 newborn rats. Seven rats were treated for 8 weeks followed by 8 weeks without lithium and seven for 16 weeks . Plasma urea and renal concentrating ability were measured, and one kidney fixed by vascular perfusion. Mean glomerular volume as well as volumes of individual glomeruli were estimated. In addition, the structural integrity between the glomerulus and the proximal tubule was investigated on serial sections. No sclerotic glomeruli were present. Only 37.6 and 27.9% of the glomeruli in the Li/C and Li/Li groups, respectively, were connected to a normal proximal tubule, and most remaining glomeruli were atubular. The mean glomerular volume was unchanged in the Li/C group and reduced by 40% in the Li/Li group. The intraindividual variation in glomerular volume was about 10-fold larger in the lithium-treated groups than in controls. The glomeruli connected to normal proximal tubules had the largest volumes, and hypertrophied glomeruli were encountered more frequently in the Li/C group than in the Li/Li group. There was a significant positive correlation between the plasma urea and the fraction of glomeruli that were not connected to normal proximal tubules. While there has been some indication of adverse effects on fetuses following lithium treatment, none was observed in rats, rabbits or primates. This dose to rats was sufficient to produce maternal toxicity and effects on the pups of treated, lactating dams. |
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