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*This document is like a lab demo—an example Certificate of Analysis (COA) that showcases what a COA looks like but may not match the latest batch in all its glory. Think of it as a chemistry experiment: close, but not quite the final reaction!
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Bulk Quote| IUPAC name | trimethyl phosphate |
| canonical smiles | COP(=O)(OC)OC |
| inchi | InChI=1S/C3H9O4P/c1-5-8(4,6-2)7-3/h1-3H3 |
| inchi key | WVLBCYQITXONBZ-UHFFFAOYSA-N |
| molecular formula | C3H9O4P |
| synonyms | |
| Compound Description |
| Molecular Weight: | 140.07 g/mol |
| XLogP3: | -0.5 |
| Hydrogen Bond Donor Count: | 0 |
| Hydrogen Bond Acceptor Count: | 4 |
| Rotatable Bond Count: | 3 |
| Exact Mass: | 140.02384576 g/mol |
| Monoisotopic Mass: | 140.02384576 g/mol |
| Topological Polar Surface Area: | 44.8 Ų |
| Heavy Atom Count: | 8 |
| Formal Charge: | 0 |
| Complexity: | 82.4 |
| Isotope Atom Count: | 0 |
| Defined Atom Stereocenter Count: | 0 |
| Undefined Atom Stereocenter Count: | 0 |
| Defined Bond Stereocenter Count: | 0 |
| Undefined Bond Stereocenter Count: | 0 |
| Covalently-Bonded Unit Count: | 1 |
| Compound Is Canonicalized: | Yes |
| Related Compounds |
| hazard signal | Danger |
| hazard classes and categories | |
| precautionary statement codes | P203, P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P351+P338, P305+P354+P338, P317, P318, P321, P330, P332+P317, P337+P317, P362+P364, P405, and P501 |
| hazard statements | |
| hazards summary | Danger of cutaneous absorption. Carcinogenicity in man cannot be assessed conclusively because of insufficient data (Group 3B). Germ cell mutagens that have shown to increase the mutant frequency in the progeny of exposed mammals. A skin, eye, and respiratory tract irritant. Chronic or repeated exposure may cause flaccid paralysis and genetic damage. An irritant. Targets CNS. |
| toxicity summary | IDENTIFICATION AND USE: Trimethyl phosphate is a colorless liquid. It is used as a gasoline additive for controlling surface ignition and spark plug fouling; methylating agent, chemical intermediate in the production of polymethyl polyphosphates; flame retardant solvent for paints and polymers; catalyst in the preparation of polymers and resins. HUMAN EXPOSURE AND TOXICITY: Weakness and paralysis are neurotoxic effects of trimethyl phosphate. ANIMAL STUDIES: Trimethyl phosphate was a rabbit eye irritant. In rabbits oral or dermal administration produced flaccid and spastic paralysis. Trimethyl phosphate was neurotoxic in beagle dogs. After 4 wk, neurotoxicity was noted in impairment of hopping, tactile placing, and atactic gait. Electrophysiologic tests indicated a prolonged latency of neuromuscular impulse transmission after wk 9, followed by a decrease in maximum conduction velocity of sensory fibers. Peripheral nerve fibers also had abnormalities at this time, including paranodal and internodal swelling, paranodal demyelination, and distal fragmentation. Trimethyl phosphate induced sterility in mice, rats and rabbits. Trimethyl phosphate primarily affected epididymal spermatozoa, probably by action of sperm motility. Trimethyl phosphate causes aspermia in D. melanogaster males. Evidence from cytological studies of larval testes suggests that the chemosterilizing effect of the chemical is upon early primary spermatocytes. In developmental studies in mice, F1 male progeny were sterile or semi-sterile, resulting from heritable translocations. Thus, trimethyl phosphate is capable of causing chromosomal damage in mouse spermatids. in NTP carcinogenicity studies trimethyl phosphate was associated with the induction of benign fibromas of the subcutaneous tissue in male Fischer rats. No evidence of carcinogenicity of the compound was obtained in female rats. Trimethylphosphate was carcinogenic in female mice, inducing adenocarcinomas of the uterus/endometrium. No evidence of carcinogenicity of the compound was obtained in male mice. ECOTOXICITY STUDIES: In Japanese quail treated orally with trimethyl phosphate, there was rapid decline in the percentage of fertile eggs during the 10 day period following the first dose. In another study it was reported that only 81% of eggs laid between 1 and 35 days after treatment of male quail with trimethyl phosphate were fertile, significantly less than in the control group . |
| symptoms | Inhalation Symptoms: Cough. Sore throat. Skin Symptoms: Redness. Eye Symptoms: Redness. Ingestion Symptoms: Shortness of breath. Weakness. Hyperexcitability. Tremor. |
