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Product No: AA6177

N,N-Dimethylacetamide , for HPLC, ≥99.9% CHROMASOLV® Plus

Name: N,N-Dimethylacetamide
Brand: Chempure

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CAS Number

127-19-5

Molecular Weight

87.12

Formula

CH3CON(CH3)2

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IUPAC name	N,N-dimethylacetamide
canonical smiles	CC(=O)N(C)C
inchi	InChI=1S/C4H9NO/c1-4(6)5(2)3/h1-3H3
inchi key	FXHOOIRPVKKKFG-UHFFFAOYSA-N
molecular formula	C4H9NO
synonyms	N,N-DIMETHYLACETAMIDE 127-19-5 Dimethylacetamide Acetamide, N,N-dimethyl- DMAc
Compound Description	Dimethylacetamide appears as a clear colorless liquid with a faint odor similar to ammonia. About the same density as water. Flash point 145 °F. Vapors heavier than air. May by toxic by skin absorption. May irritate eyes and skin. N,N-dimethylacetamide is a member of the class of acetamides that is acetamide in which the hydrogens attached to the N atom have been replaced by two methyl groups respectively. Metabolite observed in cancer metabolism. It has a role as a human metabolite. It is a member of acetamides and a monocarboxylic acid amide. It is functionally related to an acetamide. N,N-Dimethylacetamide is a dipolar aprotic solvent and reagent that may be used in the production of fibers and pharmaceuticals, and as a non-aldehyde fixative.

Computed Properties

Molecular Weight:	87.12 g/mol
XLogP3:	-0.8
Hydrogen Bond Donor Count:	0
Hydrogen Bond Acceptor Count:	1
Rotatable Bond Count:	0
Exact Mass:	87.068413911 g/mol
Monoisotopic Mass:	87.068413911 g/mol
Topological Polar Surface Area:	20.3 Å²
Heavy Atom Count:	6
Formal Charge:	0
Complexity:	58.6
Isotope Atom Count:	0
Defined Atom Stereocenter Count:	0
Undefined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
Covalently-Bonded Unit Count:	1
Compound Is Canonicalized:	Yes

Related Compounds

N,N-Dimethylformamide

Peracetic Acid

Ethyl formate

Acetone

Urethane

Methyl Ethyl Ketone

Ethyl Acetate

Methyl methacrylate

2-Pentanone

Vinyl acetate

Methyl acetate

N,N-Dimethylacetamide

Acetic Anhydride

Epichlorohydrin

Chloroacetone

hazard signal	Danger
hazard classes and categories	Acute Tox. 4 (99.41%) Eye Irrit. 2A (32.62%) Acute Tox. 4 (96.47%) Repr. 1B (96.38%) Carcinogenicity - Category 2 Acute toxicity (Inhalation: Vapours) - Category 3 Acute toxicity (Inhalation: Dusts and mists) - Category 4 Serious eye damage/eye irritation - Category 2B Reproductive toxicity - Category 1B Specific target organ toxicity - Single exposure - Category 3 (Narcotic effects) Specific target organ toxicity - Repeated exposure - Category 1 (liver), Category 2 (respiratory system) Flammable liquids - Category 4 Serious eye damage/eye irritation - Category 2 Carcinogenicity - Category 1B Specific target organ toxicity - Single exposure - Category 1 (central nervous system, liver), Category 3 (narcotic effects) Specific target organ toxicity - Repeated exposure - Category 1 (liver, respiratory organs) Flammable - 2nd degree Repr. 1B Acute Tox. 4 *
precautionary statement codes	P203, P261, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P317, P318, P321, P337+P317, P362+P364, P405, and P501
hazard statements	H312 (99.41%): Harmful in contact with skin [Warning Acute toxicity, dermal] H319 (32.62%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H332 (96.47%): Harmful if inhaled [Warning Acute toxicity, inhalation] H360 (96.38%): May damage fertility or the unborn child [Danger Reproductive toxicity]
hazards summary	Toxic hepatitis has been reported in workers after inhalation and dermal exposure. DMAC is fetotoxic and teratogenic when administered at high doses to rabbits and rats. NOAEL = 25 ppm for hepatic and renal toxicity in rats and mice. Humans exposed to high doses may experience mental confusion. A skin and eye irritant. Inhalation of high concentrations may cause liver and CNS effects. In a study of 440 new elastone fiber workers, 28 cases with elevated liver enzymes were detected in a 31 month period from 2002 to 2004. Using the BEI of 30 mg/g creatinine as a cutoff, the incidence of hepatic injury was about 7 times greater in the high exposure group.

symptoms	irritation skin. jaundice, liver damage. depression, drowsiness, hallucinations, delusions
carcinogen classification	IARC Carcinogenic Agent: N,N-Dimethylacetamide
carcinogen classification	IARC Carcinogenic Classes: Group 2B: Possibly carcinogenic to humans
carcinogen classification	IARC Monographs: Volume 123: Some Nitrobenzenes and Other Industrial Chemicals

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About this item

Documentation

Certificate of Analysis

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*This document is like a lab demo—an example Certificate of Analysis (COA) that showcases what a COA looks like but may not match the latest batch in all its glory. Think of it as a chemistry experiment: close, but not quite the final reaction!

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About this item

IUPAC name	N,N-dimethylacetamide
canonical smiles	CC(=O)N(C)C
inchi	InChI=1S/C4H9NO/c1-4(6)5(2)3/h1-3H3
inchi key	FXHOOIRPVKKKFG-UHFFFAOYSA-N
molecular formula	C4H9NO
synonyms	N,N-DIMETHYLACETAMIDE 127-19-5 Dimethylacetamide Acetamide, N,N-dimethyl- DMAc
Compound Description	Dimethylacetamide appears as a clear colorless liquid with a faint odor similar to ammonia. About the same density as water. Flash point 145 °F. Vapors heavier than air. May by toxic by skin absorption. May irritate eyes and skin. N,N-dimethylacetamide is a member of the class of acetamides that is acetamide in which the hydrogens attached to the N atom have been replaced by two methyl groups respectively. Metabolite observed in cancer metabolism. It has a role as a human metabolite. It is a member of acetamides and a monocarboxylic acid amide. It is functionally related to an acetamide. N,N-Dimethylacetamide is a dipolar aprotic solvent and reagent that may be used in the production of fibers and pharmaceuticals, and as a non-aldehyde fixative.

Computed Properties

Molecular Weight:	87.12 g/mol
XLogP3:	-0.8
Hydrogen Bond Donor Count:	0
Hydrogen Bond Acceptor Count:	1
Rotatable Bond Count:	0
Exact Mass:	87.068413911 g/mol
Monoisotopic Mass:	87.068413911 g/mol
Topological Polar Surface Area:	20.3 Å²
Heavy Atom Count:	6
Formal Charge:	0
Complexity:	58.6
Isotope Atom Count:	0
Defined Atom Stereocenter Count:	0
Undefined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
Covalently-Bonded Unit Count:	1
Compound Is Canonicalized:	Yes

Related Compounds

N,N-Dimethylformamide

Peracetic Acid

Ethyl formate

Acetone

Urethane

Methyl Ethyl Ketone

Ethyl Acetate

Methyl methacrylate

2-Pentanone

Vinyl acetate

Methyl acetate

N,N-Dimethylacetamide

Acetic Anhydride

Epichlorohydrin

Chloroacetone

hazard signal	Danger
hazard classes and categories	Acute Tox. 4 (99.41%) Eye Irrit. 2A (32.62%) Acute Tox. 4 (96.47%) Repr. 1B (96.38%) Carcinogenicity - Category 2 Acute toxicity (Inhalation: Vapours) - Category 3 Acute toxicity (Inhalation: Dusts and mists) - Category 4 Serious eye damage/eye irritation - Category 2B Reproductive toxicity - Category 1B Specific target organ toxicity - Single exposure - Category 3 (Narcotic effects) Specific target organ toxicity - Repeated exposure - Category 1 (liver), Category 2 (respiratory system) Flammable liquids - Category 4 Serious eye damage/eye irritation - Category 2 Carcinogenicity - Category 1B Specific target organ toxicity - Single exposure - Category 1 (central nervous system, liver), Category 3 (narcotic effects) Specific target organ toxicity - Repeated exposure - Category 1 (liver, respiratory organs) Flammable - 2nd degree Repr. 1B Acute Tox. 4 *
precautionary statement codes	P203, P261, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P317, P318, P321, P337+P317, P362+P364, P405, and P501
hazard statements	H312 (99.41%): Harmful in contact with skin [Warning Acute toxicity, dermal] H319 (32.62%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H332 (96.47%): Harmful if inhaled [Warning Acute toxicity, inhalation] H360 (96.38%): May damage fertility or the unborn child [Danger Reproductive toxicity]
hazards summary	Toxic hepatitis has been reported in workers after inhalation and dermal exposure. DMAC is fetotoxic and teratogenic when administered at high doses to rabbits and rats. NOAEL = 25 ppm for hepatic and renal toxicity in rats and mice. Humans exposed to high doses may experience mental confusion. A skin and eye irritant. Inhalation of high concentrations may cause liver and CNS effects. In a study of 440 new elastone fiber workers, 28 cases with elevated liver enzymes were detected in a 31 month period from 2002 to 2004. Using the BEI of 30 mg/g creatinine as a cutoff, the incidence of hepatic injury was about 7 times greater in the high exposure group.

symptoms	irritation skin. jaundice, liver damage. depression, drowsiness, hallucinations, delusions
carcinogen classification	IARC Carcinogenic Agent: N,N-Dimethylacetamide
carcinogen classification	IARC Carcinogenic Classes: Group 2B: Possibly carcinogenic to humans
carcinogen classification	IARC Monographs: Volume 123: Some Nitrobenzenes and Other Industrial Chemicals

Product No: AA6177

N,N-Dimethylacetamide , for HPLC, ≥99.9% CHROMASOLV® Plus

Product No: AA6177

About this item

NAME AND IDENTIFIERS

CHEMICAL AND PHYSICAL PROPERTIES

Related Compounds

SAFETY AND HAZARDS

TOXICITY

About this item

Documentation

Certificate of Analysis

Require a Sample Certificate of Analysis (COA) ?

Reviews

Product No: AA6177

About this item

NAME AND IDENTIFIERS

CHEMICAL AND PHYSICAL PROPERTIES

Related Compounds

SAFETY AND HAZARDS

TOXICITY

Require a Sample Certificate of Analysis (COA) ?