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*This document is like a lab demo—an example Certificate of Analysis (COA) that showcases what a COA looks like but may not match the latest batch in all its glory. Think of it as a chemistry experiment: close, but not quite the final reaction!
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Bulk Quote| IUPAC name | 2-aminoacetic acid |
| canonical smiles | C(C(=O)O)N |
| inchi | InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) |
| inchi key | DHMQDGOQFOQNFH-UHFFFAOYSA-N |
| molecular formula | C2H5NO2 |
| synonyms | |
| Compound Description |
| Molecular Weight: | 75.07 g/mol |
| XLogP3: | -3.2 |
| Hydrogen Bond Donor Count: | 2 |
| Hydrogen Bond Acceptor Count: | 3 |
| Rotatable Bond Count: | 1 |
| Exact Mass: | 75.032028402 g/mol |
| Monoisotopic Mass: | 75.032028402 g/mol |
| Topological Polar Surface Area: | 63.3 Ų |
| Heavy Atom Count: | 5 |
| Formal Charge: | 0 |
| Complexity: | 42.9 |
| Isotope Atom Count: | 0 |
| Defined Atom Stereocenter Count: | 0 |
| Undefined Atom Stereocenter Count: | 0 |
| Defined Bond Stereocenter Count: | 0 |
| Undefined Bond Stereocenter Count: | 0 |
| Covalently-Bonded Unit Count: | 1 |
| Compound Is Canonicalized: | Yes |
| Related Compounds |
| hazard signal | |
| hazard classes and categories | |
| hazard statements | |
| hazards summary | Human ingestion of 800 mg/kg causes changes in surface EEG, changes in psychological tests, and nausea or vomiting. Safe when used as a flavoring agent in food. May cause irritation. |
| toxicity summary | In the CNS, there exist strychnine-sensitive glycine binding sites as well as strychnine-insensitive glycine binding sites. The strychnine-insensitive glycine-binding site is located on the NMDA receptor complex. The strychnine-sensitive glycine receptor complex is comprised of a chloride channel and is a member of the ligand-gated ion channel superfamily. The putative antispastic activity of supplemental glycine could be mediated by glycine's binding to strychnine-sensitive binding sites in the spinal cord. This would result in increased chloride conductance and consequent enhancement of inhibitory neurotransmission. The ability of glycine to potentiate NMDA receptor-mediated neurotransmission raised the possibility of its use in the management of neuroleptic-resistant negative symptoms in schizophrenia. <br/>Animal studies indicate that supplemental glycine protects against endotoxin-induced lethality, hypoxia-reperfusion injury after liver transplantation, and D-galactosamine-mediated liver injury. Neutrophils are thought to participate in these pathologic processes via invasion of tissue and releasing such reactive oxygen species as superoxide. In vitro studies have shown that neutrophils contain a glycine-gated chloride channel that can attenuate increases in intracellular calcium and diminsh neutrophil oxidant production. This research is ealy-stage, but suggests that supplementary glycine may turn out to be useful in processes where neutrophil infiltration contributes to toxicity, such as ARDS. |
| symptoms | |
| health effects | Chronically high levels of glycine are associated with at least 12 inborn errors of metabolism including: Citrullinemia Type I, Hyperglycinemia, non-ketotic, Hyperprolinemia Type I, Hyperprolinemia Type II, Iminoglycinuria, Isovaleric Aciduria, Malonic Aciduria, Methylmalonic Aciduria, Methylmalonic Aciduria Due to Cobalamin-Related Disorders, Non Ketotic Hyperglycinemeia, Prolinemia Type II, Propionic academia and Short Chain Acyl CoA Dehydrogenase Deficiency . |
| carcinogen classification | default_key: No indication of carcinogenicity to humans . |
