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*This document is like a lab demo—an example Certificate of Analysis (COA) that showcases what a COA looks like but may not match the latest batch in all its glory. Think of it as a chemistry experiment: close, but not quite the final reaction!
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Bulk Quote| hazards summary | Methylene chloride is a colorless liquid with a mild, sweet odor. Another name for it is dichloromethane. Methylene chloride does not occur naturally in the environment.Methylene chloride is used as an industrial solvent and as a paint stripper. It may also be found in some aerosol and pesticide products and is used in the manufacture of photographic film.Methylene chloride is predominantly used as a solvent. The acute (short-term) effects of methylene chloride inhalation in humans consist mainly of nervous system effects including decreased visual, auditory, and motor functions, but these effects are reversible once exposure ceases. The effects of chronic (long-term) exposure to methylene chloride suggest that the central nervous system (CNS) is a potential target in humans and animals. Human data are inconclusive regarding methylene chloride and cancer. Animal studies have shown increases in liver and lung cancer and benign mammary gland tumors following the inhalation of methylene chloride.Evidence of liver injury in exposed workers has been reported. Some of the methylene chloride absorbed is metabolized to carbon monoxide. Non-smoking workers exposed to average concentrations of 66 ppm had carboxyhemoglobin levels of 3.6 %. This is above that permitted for exposure to carbon monoxide (3.5 %). Dichloromethane causes trivial hepatotoxicity, unless exposure is very heavy or agent ingested. In one study, 24 healthy workers chronically exposed to methylene chloride at concentrations averaging from 60 to 475 ppm were electrocardiographically monitored and showed neither an increase in ventricular or supraventricular ectopic activity nor episodic ST segment depression. Likewise, there was no evidence of cardiac susceptibility or electrographic abnormalities in several case reports of otherwise healthy persons rendered unconscious from acute exposure to methylene chloride. Methylene chloride is in the list of Some volatile substances which may be abused by inhalation published on the web site of the U.N. International Drug Control Programme, indicating its potential to cause narcosis in workers. |
| symptoms | irritation eyes, skin. lassitude , drowsiness, dizziness. numb, tingle limbs. nausea. [potential occupational carcinogen]Breathing large amounts of methylene chloride causes dizziness, nausea, tingling or numbness of the finger and toes, loss of concentration, and reduced hand-eye coordination. Very high concentrations can lead to unconciousness, coma, and death. Skin contact with methylene chloride causes burning and redness of the skin. |
| health effects | Exposure to methylene chloride may cause optic neuropathy and hepatitis. Very high concentrations can lead to unconciousness, coma, and death. It is metabolized to carbon monoxide, potentially leading to carbon monoxide poisoning. Methylene chloride also causes liver and kidney injury, and may be a carcinogen. |
| carcinogen classification | IARC Carcinogenic Agent: Dichloromethane |
| carcinogen classification | IARC Carcinogenic Classes: Group 2A: Probably carcinogenic to humans |
| carcinogen classification | IARC Monographs: Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 Volume 71: Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide Volume 110: Some Chemicals Used as Solvents and in Polymer Manufacture |
| carcinogen classification | default_key: 2A, probably carcinogenic to humans. |
